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1.[1-9]Use of 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4-thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione in the Synthesis of Novel Quinazolinone Derivatives
9 pagine
Pubblicato da
Decker Alexander
Chemical and Process Engineering Research www.
iiste.
org
ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online)
Vol 1, 2011
1 | P a g e
www.
iiste.
org
Use of...
[Di più]
Chemical and Process Engineering Research www.
iiste.
org
ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online)
Vol 1, 2011
1 | P a g e
www.
iiste.
org
Use of 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione in the
Synthesis of Novel Quinazolinone Derivatives
Khalid M Darwish (Corresponding author)
Chemistry Department, Science Faculty
University of Garyounis, Benghazi-Libya
khaliddarwish1962@yahoo.
com
Maher A El-Hashash, Sameh A Rizk, Fakhry A El-Bassiouny
Chemistry Department, Science Faculty
Ain Shams University, Abbassia, Cairo-Egypt.
Abstract
The 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4-thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione1
was synthesized and allowed to react with each of p-methoxybenzaldehyde, p-methoxyacetophenone and
chloroacetyl chloride to produce the Schiff bases 2 and 3 and 2-chloro-N-(3-{5-[(1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-oxo-3,4-dihydroquinazolin-2-yl)acetamide 6, respe
[Di meno]
Tag
affording,
amino,
anti,
chloride,
derivative,
derivatives,
dione,
ethyl,
iiste,
isoindole,
issn,
methyl,
oxoquinazolin,
potassium,
quinazolinone,
reacted,
thiadiazol
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